Lio was last seen at around 5.20pm on Wednesday (24/1) at his home address by his mother.
Lio is a mixed-race boy with light-coloured skin and is around 52ft 2ins tall with shaggy short dark brown hair and brown eyes.
He was last seen wearing a black and white t-shirt with a large skull motif, black cargo trousers with a smiley face on one pocket, a black zip-up hooded top with neon X-Box motif on the front over full torso, and plain black unbranded trainers.
Inspector Nicky Hamblin, based at Reading police station, said: “I’m issuing this appeal for help in locating Lio as we’re growing increasingly concerned for his welfare.
“He acts older than 11 years old and has a slim but fairly muscular build for his age.
“He is thought to be in the Whitley area of Reading. Naturally, given his age and the amount of time he has been missing, our concerns are growing for him.
“I would ask anybody who sees Lio to please contact us on 999, quoting reference 43240036845 or report sightings or whereabouts via our dedicated missing persons’ portal.”