Three people have been killed and a fourth person is in hospital with life-threatening injuries following a crash involving a Mondeo, a minibus and a lorry on the M25 near Waltham Abbey.
Essex Police said the crash between a lorry, a minibus and a car happened between the junctions for Waltham Abbey and the M11 at about 18:15 BST.
The motorway remains closed anti-clockwise between junctions 26 and 27 with emergency services at the scene.
East of England Ambulance Service said it was treating a number of people involved.
Police said the road would remain closed for hours.